References
Biocatalysis References
1. Burgos, A.; Caille, J-C.; Gradley, M.L. WO2008/ 2911603. Procedure for the enzymatic chemoselective hydrolysis of a diester for the preparation of a monoester monoacid.
2. Burgos A, Caille JC, Gradley ML, Frein S, Derrien Y & Chenard E WO2007/132119. In situ or one-pot hydrogenation and reductive amination method.
3. Carr R, Alexeeva M, Dawson MJ, Gotor-Fernandez V, Humphrey CE & Turner NJ (2005) ChemBioChem 6, 637-639. Directed evolution of an amine oxidase for the preparative deracemisation of cyclic secondary amines.
4. Enright A, Alexandre FR, Roff G, Fotheringham IG, Dawson MJ & Turner NJ (2003) Chem. Commun. 2636-2637. Stereoinversion of β and γ-substituted α-amino acids using a chemo-enzymatic oxidation-reduction procedure.
5. Carr R, Alexeeva M, Enright A, Eve TSC, Dawson MJ & Turner NJ (2003) Angew. Chem. Int. Ed. 42, 4807-4810. Directed evolution of an amine oxidase possessing both broad substrate specificity and high enantioselectivity.
6. Alexeeva M, Enright A, Dawson MJ, Mahmoudian M, Turner NJ (2002) Angew. Chem. Int. Ed. Engl. 41, 3177-3180. Deracemization of α-methylbenzylamine using an enzyme obtained by in vitro evolution.
7. Gradley, M.L., Trivett, A.J., Willets, A.J., Chatakondu, K., Robins, K.G., Cheetham, P.S.J., Walls, M., Alston, M.J. WO2007/0205655. Flavour product.
8. Hall RM, Dawson MJ, Jones CA, Roberts AD, Sidebottom PJ, Stead P & Taylor NL (2001) J. Antibiotics 54, 948-957. The production of novel sordarin analogues by biotransformation.
9. Taylor M, Lamb DC, Cannell RJP, Dawson MJ & Kelly SL (2000) Biochem. Biophys. Res. Commun. 279, 708-711. Cofactor recycling with immobilized heterologous cytochrome P450 105D1 (CYP105D1).
10. Taylor M, Lamb DC, Cannell R, Dawson M & Kelly SL (1999) Biochem. Biophys. Res. Commun. 263, 838-842. Cytochrome P450105D1 (CYP105D1) from Streptomyces griseus: heterologous expression, activity and activation effects of multiple xenobiotics.
11. Gradley, M.L., Willetts, A.J., Sime,J.T. WO2000/ 0047758. Methods of making compounds.
12. Cheetham, P.S.J., Gradley, M.L. and Sime, J.T. WO2000/0050622. Flavour/ aroma materials and their preparations.
13. Blayer S, Woodley JM, Dawson MJ & Lilly MD (1999) Biotechnol. Bioengng. 66, 131-136. Alkaline biocatalysis for the direct synthesis of N-acetyl-D-neuraminic acid (Neu5Ac) from N-acetyl-D-glucosamine.
14. Mahmoudian M, Lowdon A, Jones M, Dawson M & Wallis C (1999) Tetrahedron: Asymmetry 10, 1201-1206. A practical enzymatic procedure for the resolution of N-substituted 2-azabicyclo[2.2.1]hept-5-en-3-one.
15. Mahmoudian M, Eaddy J & Dawson M (1999) Biotechnol. Appl. Biochem. 29, 229-233. Enzymic acylation of 506U78 (2-amino-9-ƒÒ-D-arabinofuranosyl-6-methoxy-9H-purine), a powerful new anti-leukaemic agent.
16. Dawson MJ, Mahmoudian M & Wallis CJ (1999) PCT Int. App. WO9910519 A1 19990304. Process for preparing enantiomerically enriched N-derivatized lactams.
17. Mahmoudian M, Rudd BAM, Cox B, Drake CS, Hall RM, Stead P, Dawson MJ, Chandler M, Livermore DG, Turner NJ & Jenkins G (1998) Tetrahedron 54, 8171-8182. A versatile procedure for the generation of nucleoside 5'-carboxylic acids using nucleoside oxidase.
18. Mahmoudian M, Noble D, Drake CS, Middleton RF, Montgomery DS,Piercey JE, Ramlakhan D, Todd M & Dawson MJ (1997) Enzyme Microb. Technol. 20, 393-400. An efficient process for production of N-acetylneuraminic acid using N-acetylneuraminic acid aldolase.
19. Mahmoudian M, Baines BS, Drake CS, Hale RS, Jones P, Piercey JE, Montgomery DS, Purvis IJ, Storer R, Dawson MJ & Lawrence GC (1993) Enzyme Microb. Technol. 15, 749-755. Enzymatic production of optically pure (2'R-cis)-2'-deoxy-3'-thiacytidine (3TC, lamivudine): a potent anti-HIV agent.
Metabolites References
1. Brazier-Hicks M, Offen W, Gershater M, Revett T, Lim E, Bowles D, Davies G, Edwards R (2007) Proceedings of the National Academy of Sciences 104 (51): 20238-20243. Characterization and engineering of the bifunctional N- and O-glucosyl transferase involved in xenobiotic metabolism in plants.
2. Gershater M, Cummins I, Edwards R (2007) Journal of Biological Chemistry 282 (29) 21460-21466. Role of a carboxylesterase in herbicide bioactivation in Arabidopsis thaliana.
3. Gershater M, Edwards R (2007) Plant Science 173 (6): 579-588. Regulating biological activity in plants with carboxylesterases.
4. Sime J (2006) Speciality Chemicals Magazine March 2006. Microbial Systems to Mimic Mammalian Metabolism.
5. Gershater M, Sharples K, Edwards R (2006) Phytochemistry 67 (23): 2561- 2567. Carboxylesterase activities toward pesticide esters in crops and weeds.
6. Todd M, Drake CS, Rudd BAM, Roberts DW, Clarkson-Jones J, Booth M, Lenz E, Phillips P & Dawson MJ (2005) Biotrans 2005 Poster Presentation. Metabolite Factories: use of microbial systems to generate metabolites of ZD4054, an endothelin receptor antagonist.
7. Hall RM, Dawson MJ, Jones CA, Roberts AD, Sidebottom PJ, Stead P & Taylor NL (2001) J. Antibiotics 54, 948-957. The production of novel sordarin.
8. Taylor M, Lamb DC, Cannell RJP, Dawson MJ & Kelly SL (2000) Biochem. Biophys. Res. Commun. 279, 708-711. Cofactor recycling with immobilized heterologous cytochrome P450 105D1 (CYP105D1).
9. Taylor M, Lamb DC, Cannell R, Dawson M & Kelly SL (1999) Biochem. Biophys. Res. Commun. 263, 838-842. Cytochrome P450105D1 (CYP105D1) from Streptomyces griseus: heterologous expression, activity and activation effects of multiple xenobiotics.
10. Blackaby A, Dawson MJ, Hall RM, Jones CA, Knaggs AR, Marshall PS, Taylor NL, Sidebottom P & Webb G (1998) in 'New Frontiers in Screening for Microbial Biocatalysts' (Kieslick K, van der Beek CP, de Bont JAM & van den Tweel WJJ ed) pp 173-176. Elsevier. Production of novel derivatives of a gastrin antagonist (GW1) using biotransformation.
11. Cannell RJP, Knaggs AR, Dawson MJ, Manchee GR, Eddershaw PJ, Waterhouse I, Sutherland DR, Bowers GD & Sidebottom PJ (1995) Drug Metab. Disposition 23, 724-729. Microbial biotransformation of the angiotensin II antagonist GR117289 by Streptomyces rimosus to identify a mammalian metabolite.