Publications
Biofuels References
1. Atkinson A, Cripps R, Rudd B, Eley K, Martin S, Milner P & Mercier C WO2008/038019. Thermophilic microorganisms for ethanol production.
2. Atkinson A, Cripps R, Thompson A, Eley K, Taylor M, Leak D, Rudd B & Baker S WO2006/131734. Modified microorganisms with inactivated lactate dehydrogenase gene.
3. Atkinson A, Cripps R, Eley K, Rudd B & Todd M WO2006/117536. Thermophilic microorganisms with inactivated lactate dehydrogenase gene (LDH) for ethanol production.
Pathway Engineering of Natural Products References
4. Appleyard AN & Dawson MJ (2008) Speciality Chemical Magazine May 2008. The pathway to engineered natural products.
5. Boakes S, Cortes J & Dawson MJ WO2007/083112. Lantibiotic biosynthetic gene clusters from A. garbadinensis and A. liguriae.
6. Dawson MJ, Cortes J & Appleyard AN WO2007/036706. Variants of the lantibiotic Mersacidin and their use.
7. Dawson MJ, Cortes J, Rudd BAM, Boakes S, Bierbaum G, Hoffmann A & Schmitz S WO2005/093069. Production of Mersacidin and its Variants in ∆SigH and/or ∆MrsA Bacillus Host Cells.
8. Boakes S, Oliynyk M, Cortes J, Bohm I, Rudd BA, Revill WP, Staunton J, Leadlay PF. (2004) J Mol Microbiol Biotechnol. 8, 73-80. A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.
9. Del Vecchio F, Petkovic H, Kendrew SG, Low L, Wilkinson B, Lill R, Cortes J, Rudd BA, Staunton J, Leadlay PF. (2003) J Ind Microbiol Biotechnol. 30, 489-94. Active-site residue, domain and module swaps in modular polyketide synthases.
10. Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J (2002) Chem Biol. 9, 1175-87. Structure, Biosynthetic Origin, and Engineered Biosynthesis of Calcium-Dependent Antibiotics from Streptomyces coelicolor.
11. Long PF, Wilkinson CJ, Bisang CP, Cortes J, Dunster N, Oliynyk M, McCormick E, McArthur H, Mendez C, Salas JA, Staunton J, Leadlay PF (2002) Mol Microbiol. 43, 1215-25. Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase.
12. Ostergaard LH, Kellenberger L, Cortes J, Roddis MP, Deacon M, Staunton J, Leadlay PF (2002) Biochemistry 26, 2719-26. Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase.
13. Nicholson TP, Rudd BAM, Dawson M, Lazarus CM, Simpson TJ & Cox RJ (2001) Chem. Biol. 8, 157-178. Design and utility of oligonucleotide gene probes for fungal polyketide synthases.
14. Leadlay PF, Staunton J, Oliynyk M, Bisang C, Cortes J, Frost E, Hughes-Thomas ZA, Jones MA, Kendrew SG, Lester JB, Long PF, McArthur HA, McCormick EL, Oliynyk Z, Stark CB, Wilkinson CJ (2001) J Ind Microbiol Biotechnol. 27, 360-7. Engineering of complex polyketide biosynthesis-insights from sequencing of the monensin biosynthetic gene cluster.
15. Rowe CJ, Bohm IU, Thomas IP, Wilkinson B, Rudd BAM, Foster G, Blackaby A, Sidebottom PJ, Roddis Y, Buss AD, Staunton J & Leadlay PF (2001) Chem. Biol. 8, 475-485. Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase.
16. Holzbaur IE, Ranganathan A, Thomas IP, Kearney DJA, Reather JA, Rudd BAM, Staunton J & Leadlay PF (2001) Chem. Biol. 8, 329-340. Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates.
17. Kaur H, Cortes J, Leadlay P, Lal R (2001) Microbiol Res. 156, 239-46. Cloning and partial characterization of the putative rifamycin biosynthetic gene cluster from the actinomycete Amycolatopsis mediterranei DSM 46095.
18. Nicholson TP, Rudd BAM, Dawson M, Lazarus CM, Simpson TJ & Cox RJ (2001) Chem. Biol. 8, 157-178. Design and utility of oligonucleotide gene probes for fungal polyketide synthases.
19. Wilkinson B, Foster G, Rudd BAM, Blackaby AP, Sidebottom PJ, Cooper DJ, Dawson MJ, Buss AD, Gaisser S, Bohm IU, Rowe CJ, Cortes J, Leadley PF & Staunton J (2000) Chem. Biol. 7, 111-117. Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase.
20. Holzbaur IE, Harris RC, Bycroft M, Cortes J, Bisang C, Staunton J, Rudd BAM & Leadlay PF (1999) Chem. Biol. 6, 189-195. Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase.
21. Ranganathan A, Timoney M, Bycroft M, Cortes J, Thomas IP, Wilkinson B, Kellenberger L, Hanefeld U, Galloway IS, Staunton J, Leadlay PF (1999) Chem Biol. 6, 731-41. Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.
22. Bisang C, Long PF, Cortes J, Westcott J, Crosby J, Matharu AL, Cox RJ, Simpson TJ, Staunton J, Leadlay PF (1999) Nature 401, 502-5. A chain initiation factor common to both modular and aromatic polyketide synthases.
23. Gaisser S, Bohm GA, Doumith M, Raynal MC, Dhillon N, Cortes J, Leadlay PF (1998) Mol Gen Genet. 258, 78-88. Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.
24. Rowe CJ, Cortes J, Gaisser S, Staunton J, Leadlay PF (1998) Gene 17, 215-23. Construction of new vectors for high-level expression in actinomycetes.
25. Bohm I, Holzbaur IE, Hanefeld U, Cortes J, Staunton J, Leadlay PF (1998) Chem Biol. 5, 407-12. Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension.
26. Salah-Bey K, Doumith M, Michel JM, Haydock S, Cortes J, Leadlay PF, Raynal MC (1998) Mol Gen Genet. 257, 542-53. Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea.
27. Marsden AF, Wilkinson B, Cortes J, Dunster NJ, Staunton J, Leadlay PF (1998) Science 279, 199-202. Engineering broader specificity into an antibiotic-producing polyketide synthase.
28. Cortes J, Wiesmann KE, Roberts GA, Brown MJ, Staunton J, Leadlay PF (1995) Science 268, 1487-9. Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage.
29. Cortes J, Haydock SF, Roberts GA, Bevitt DJ, Leadlay PF (1990) Nature 348, 176-8. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.
30. Hopwood DA, Malpartida F, Kieser HM, Ikeda H, Duncan J, Fujii I, Rudd BAM, Floss HG & Omura S (1985) Nature 314, 642-644. Production of ‘hybrid' antibiotics by genetic engineering.